Background: The use of adjuvant tamoxifen therapy in the treatment of estrogen receptor (ER) expressing breast carcinomas represents a major advance in personalized cancer treatment.Because there is no benefit (and indeed there is increased morbidity and mortality) associated with the use of tamoxifen therapy in ER-negative breast cancer, its use i
The three waist deep dvd transcription factors, PDX1, NGN3 and MAFA, are very important in pancreatic development.Overexpression of these three factors can reprogram both pancreatic exocrine cells and SOX9-positive cells of the liver into cells resembling pancreatic beta cells.In this study we investigate whether other cell types can be reprogramme
Severe acute respiratory syndrome coronavirus-2 (SAR-CoV-2) is a highly contagious infectious disease and spreads through aerosols and fomites.Health care personnel who are at the forefront of the fight against coronavirus disease-19 (COVID-19) pandemic are also at greater risk of contracting the infection.Mixing of uninfected people enchanted wond
Environmental catastrophes, perpetuated by the unsustainable and unrestricted consumption of resources, are becoming increasingly apparent.Although elite practices often account for a disproportionate amount of resource usage, wealthy ways of life remain unchallenged while the non-elite continuously adapt to ecological crises.The cases of celebrity